Vaccine effective less than half the time?

Today the FDA indicated that clinical trials of the two-shot Sanofi Aventis SA vaccine against H5N1 was less effective than previously believed.
 

Center for Disease ControlToday a news report from AP suggested that the leading vaccine for humans stimulates a protective immune response in fewer than half of the patients involved in clinical trials. A March 2006 report in the New England Journal of Medicine suggested that as many as 54% of patients would benefit from the vaccine. Vaccine effectiveness is assessed by measuring the antibodies patients develop against H5N1.

This level of effectiveness should be compared to seasonal flu vaccines, which protect 75-90% of vaccinated adults younger than 65.

Simulations for vaccine utilization by communities or medical facilities should take into account this effectiveness level when modeling the effects of vaccinating health workers, first responders, military personnel and other critical personnel.


News
2007-06-05 Indonesian Death Toll at 79
The Associated Press reported that 79 Indonesians have died of H5N1.
2007-05-02 U.S. National Biosurveillance Integration System
Proposed DHS system to give the agency real time data from systems maintained by other agencies.
2007-05-02 About PandemicSimulation.com
Preparing for a pandemic requires expertise that is both broad and deep. PandemicSimulation.com seeks to deepen understanding of modeling, game and simulation issues, to foster community contributions to common needs and to build software solutions.
2007-05-02 adlCommunity.net to use Moodle
The US DoD Advanced Distributed Learning initiative created a new virtual community, adlCommunity.net, and selected Moodle products to power it.
2007-04-18 FDA Approves First U.S. Vaccine vs. H5N1
The sanofi pasteur vaccine, which demonstrated effectiveness for about half of the humans receiving it during test trials, will be stockpiled by the U.S. Government and will not be sold commercially.
More news…
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